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If you are asking investors to invest into a foreign entity, get legal and tax experts to prepare the memos for them about the tax impact on their fund, governance of foreign corporation etc. R&D outside SV is normally cheaper, so it helps you keeping your burnrate low. Read Venture Hacks ( [link] ).
Some angel investors join together in syndicates. At one extreme is the sort of pork-barrel project wherea town gets money from the state government to renovate a vacantbuilding as a "high-tech incubator," as if it were merely lack ofthe right sort of office space that had till now prevented the townfrom becoming a startup hub.
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Burn Rate 
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